Auction House reported a busy and profitable August, with a success rate of 82 per cent – five percentage points ahead of 2015’s figure of 77 per cent – and a month which included the sale of the group’s 2,000th property this year.The auctioneer held seven sales across the country, selling 113 lots from 137 offered, raising £12m. Cumulative results are also ahead of last year; sales in the first eight months of 2016 totalled 2,044 lots, at a cumulative success rate of 78 per cent, raising over £275m.A success rate of 82% with 113 lots sold and revenues of £12m make a total of £275m so far in 2016.The 2,000th property sold was Kirk House & Old Manse in Laurencekirk, Aberdeenshire (pictured), with five bedrooms in the former church and four bedrooms in the manse next door, which sold at Auction House Scotland’s auction in Glasgow on 25th August, for £390,000.Director Roger Lake said, “This is another set of excellent figures during a challenging time for the industry, but we are now getting back to usual volumes.”auction Auction House Auction House sales auction lots November 2, 2016The NegotiatorWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed.Related articles Letting agent fined £11,500 over unlicenced rent-to-rent HMO3rd May 2021 BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Home » News » Housing Market » Hallelujah! Auction House sells 2,000th lot this year previous nextHousing MarketHallelujah! Auction House sells 2,000th lot this yearThe Negotiator2nd November 20160520 Views
“It is clear that we face a battle for the heart and soul of our country. Instead of accepting the path the Conservatives are taking us on, imagine a United Kingdom that is more equal and compassionate, where politicians at all levels cooperate with each other on issues like tackling the climate crisis and electoral reform. Moran, an MP since the 2017 General Election, beat the Conservative PPC by almost 9,000 votes to maintain her seat. “I’m finding that we have strong support and credibility at a local level, but we need to set out a clear and positive vision in order to win back support nationally. The leadership contest follows the resignation of Jo Swinson, who was forced to resign as leader of the party after losing her Dunbartonshire East seat to the Scottish National Party. Layla Moran was re-elected as MP for the marginal Oxford West and Abingdon in December. Layla Moran said: “The message I’m hearing on the doorsteps is that the Liberal Democrats need to move on from the last decade, and put forward a positive vision for the future. This is what I intend to do as the leader of the party, and I’ll continue to listen to the ideas and opinions of both members and voters over the coming months. Oxford West and Abingdon’s MP, Layla Moran, intends to stand for Leader of the Liberal Democrats, it was announced today. “I want to lead and empower the Liberal Democrats to fight for this future and to grow our support, so that we can make people’s lives better. I want the party to be in a position to win power within a generation, so that we can bring about the change our country so desperately needs.”
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When people become infected by HIV, it’s usually only a matter of time, barring drug intervention, until they develop full-blown AIDS. However, a small number of people exposed to the virus progress very slowly to AIDS — and some never develop the disease at all.In the late 1990s, researchers showed that a very high percentage of those naturally HIV-immune people, who represent about one in 200 infected individuals, carry a gene called HLA B57. Now a team of Harvard and MIT researchers from the Ragon Institute of Massachusetts General Hospital, MIT and Harvard has revealed a new effect that contributes to this gene’s ability to confer immunity.The research team, led by Harvard Medical School (HMS) professor Bruce Walker, Director of the Ragon Institute, and MIT Professor Arup Chakraborty found that the HLA B57 gene causes the body to make more potent killer T cells — white blood cells that help defend the body from infectious invaders. Patients with the gene have a larger number of T cells that bind strongly to more pieces of HIV protein than people who do not have the gene. Thismakes the T cells more likely to recognize cells that express HIV proteins, including mutated versions that arise during infection. This effect contributes to superior control of HIV infection (and any other virus that evolves rapidly), but it also makes those people more susceptible to autoimmune diseases, in which T cells attack the body’s own cells.These findings, published in today’s edition of the journal Nature, could help researchers develop vaccines that provoke the same response to HIV that individuals with HLA B57 muster on their own, says Walker.“HIV is slowly revealing itself,” says Walker. “This is another point in our favor in the fight against the virus, but we have a long way to go.”Most killer T cells are genetically unique and recognize different pieces of foreign proteins, known as epitopes, attached to the surface of cells that have been infected by viruses or bacteria. After a killer T cell grabs hold of such a protein, it becomes activated and starts sweeping the body for more cells that express the same protein, so it can kill them. It also clones itself to produce an army of T cells targeting the invader.The new Ragon Institute study shows that individuals with the HLA B57 gene produce larger numbers of killer T cells that are cross-reactive, meaning they can attack more than one epitope associated with HIV, including mutants that arise to escape activated killer T cells.The finding offers hope that researchers could design a vaccine to help draw out cross-reactive T cells in people who don’t have the HLA B57 gene. “It’s not that they don’t have cross-reactive T cells,” says Chakraborty. “They do have them, but they’re much rarer, and we think they might be coaxed into action with the right vaccine.”The work is a valuable contribution to scientists’ understanding of HIV, says David Baltimore, professor of biology and former president of Caltech.“This is a remarkable paper because it starts from a clinical observation, integrates it with experimental observations, generates a valuable model and derives from the model a deep understanding of the behavior of the human immune system. Rarely does one read a paper that stretches the mind so surprisingly far,” says Baltimore, a Nobel laureate in physiology or medicine who now studies HIV and human T cell interactions.Chakraborty and colleagues had previously developed computational models of T-cell development in the thymus, an organ located behind the breastbone through which T cells must pass in order to become mature killers. There they undergo a selection process designed to weed out cells that might attack the body’s own cells (which display pieces of human proteins on their surface). T cells must also demonstrate that they can bind weakly to some human protein fragments. Only a tiny percentage of T cells pass these tests and are allowed to leave the thymus and circulate in the body to defend against viruses, other diseases, and cancerous cells.Inside the thymus, T cells are exposed to “self-peptides” — small human protein fragments — bound to HLA proteins. Chakraborty and co-workers had previously shown that the diversity of self-peptide fragments presented in the thymus influences the kinds of T cells a person can produce. The type and number of self-peptides expressed are determined by the HLA genes, which have hundreds of distinct forms, including HLA B57. Each person carries up to six of them (three inherited from each parent).Using data from previous studies, the Ragon team found that HLA B57 protein presents fewer types of self-peptides than most other HLA proteins. (HLA B27 is another protein that presents few types of self-peptides and also appears to protect against HIV and promote autoimmune disorders.) In this study, Chakraborty and postdoctoral fellow Elizabeth Read and graduate student Andrej Kosmrlj, lead authors of the paper, used their computer model to study what happens when maturing T cells are exposed to only a small diversity of self-peptides in the thymus.T cells with receptors that bind strongly to any of the self-peptides in the thymus are forced to undergo cell suicide, because of their potential to attack the body’s own cells. Chakraborty and co-workers showed that this means that, for most individuals, most of the body’s T cells have receptors that bind to targeted viral proteins via a number of weak interactions, with each interaction making a significant contribution to the binding. Thus, a singlemutation to an HIV peptide can potentially evade the immune response.A different scenario unfolds in people who have the HLA B57 gene. Using their computer model, Chakraborty and colleagues showed that, because those individuals’ T cells are exposed to fewer self-peptides in the thymus, T cells with receptors that mediate strong binding to viral proteins via just a few important contacts are more likely to escape the thymus. This makes these T cells more cross-reactive to targeted HIV peptide mutants, because as long as those points in the viral proteins don’t mutate, the T cells are still effective. The model also showed that once those T cells are released into the bloodstream, they can effectively attack HIV proteins, even when the virus mutates.This model also explains why people with the HLA B57 gene have autoimmune problems: Their T cells are more likely to bind strongly to human peptides not encountered in the thymus.The computational studies explained many puzzles, but also made a prediction: Individuals with HLA genes that result in a display of fewer self-peptides should control HIV (and other viruses like hepatitis C virus) better. To test this prediction, the researchers studied nearly 2,000 patients — 1,100 “HIV controllers” and 800 who progressed normally to AIDS, and confirmed that this appears to be true.
This spring, alumni can vote for a new group of Harvard Overseers and Harvard Alumni Association (HAA) elected directors.Ballots will be mailed no later than April 1 and must be received back in Cambridge by noon on May 24 to be counted. Results of the election will be announced at the HAA’s annual meeting on May 30, on the afternoon of Commencement day. All holders of Harvard degrees, except Corporation members and officers of instruction and government, are entitled to vote for Overseer candidates. The election for HAA directors is open to all Harvard degree holders.Candidates for Overseer may also be nominated by petition, that is, by obtaining a prescribed number of signatures from eligible degree holders. The deadline for all petitions is Feb. 1.The HAA’s nominating committee has proposed the following candidates in 2013:For Overseer:Susan L. Carney ’73, J.D. ’77Circuit Judge, U.S. Court of Appeals for the Second CircuitHamden, Conn.Christopher B. Field ’75Director, Department of Global Ecology, Carnegie Institution for Science; Melvin and Joan Lane Chair in Interdisciplinary Environmental Studies, Stanford UniversityStanford, Calif.Deanna Lee ’84Chief Communications and Digital Strategies Officer, Carnegie Corporation of New YorkNew YorkWalter H. Morris Jr. ’73, M.B.A. ’75Retired Principal, Ernst & Young LLPPotomac, Md.Gilbert S. Omenn, M.D. ’65Professor of Internal Medicine, Human Genetics, and Public Health and Director of the Center for Computational Medicine and Bioinformatics, University of MichiganAnn Arbor, Mich.Sanjay H. Patel ’83, A.M. ’83Managing Partner and Head of International Private Equity, Apollo Management International LLPLondonAna Maria Salazar, J.D. ’89Anchor, “Imagen News”/“Living in Mexico”/“El Primer Cafe”; CEO, Grupo SalazarMexico CityGwill York ’79, M.B.A. ’84Managing Director and Co-Founder, Lighthouse Capital PartnersCambridge, Mass.For elected director:Theodore “Ted” H. Ashford III ’86President, Ashford Capital ManagementWilmington, Del.Richard R. Buery Jr. ’92President and CEO, The Children’s Aid SocietyNew YorkPatrick S. Chung ’96, J.D. ’04, M.B.A. ’04Partner, NEAMenlo, Calif.Shilla Kim-Parker ’04, M.B.A. ’09Senior Director, Strategy and Business Development, Lincoln Center for the Performing ArtsNew YorkLori Lesser ’88, J.D. ’93Partner, Simpson Thacher & Bartlett LLPNew YorkBarbara Natterson Horowitz ’83, A.M. ’83Professor and Cardiologist, David Geffen School of Medicine at UCLA; authorLos AngelesJulie Gage Palmer ’84Lecturer in Law, University of Chicago Law SchoolChicagoArgelia M. Rodriguez, M.B.A. ’84President and Chief Executive Officer, DC College Access ProgramWashington, D.C.Jacques Salès, L.L.M. ’67Avocat à la Cour (Attorney-at-Law), Ginestié Magellan Paley-VincentParis
Help secure your “Freedom to Float” on Virginia water!This coming January, the Virginia State Senate will vote on a bill that hits close to home for any local paddler. The changes that this piece of legislation could bring are incredibly important for the outdoors community — it seeks to improve stream travel in the area and clarify the laws in place for boaters. This is a great opportunity to address some issues that have managed to slip by over over the past several years and to make paddling a more accessible sport.The bill, SB 629, reads:That the Code of Virginia is amended by adding a section numbered 29.1-745.1 as follows:Traveling upon certain waters.No person shall be liable for civil or criminal trespass for travel upon a nontidal river, stream, or creek with a drainage area of at least seven square miles within the Commonwealth if the travel consists solely of floating in or upon the water in a nonmotorized vessel for purposes of recreation. Nothing in this section shall be construed to change existing ownership rights in real property or to allow travel upon any waters where prohibited by law.The proposed changes speak to anyone with an interest in our streams. They will open up new travel options for kayakers and canoers, clear up legal confusion, and support outdoor industries. Also, there will be no affect on standing property rights for landowners–the bill would simply allow recreational and nonmotorized water vehicles to float on Virginia water.There are a number of things that you can do to get your foot in the door.First, pick up your phone. Give you state State Senator or Delegate a ring to tell them that you want their vote for SB 629, and to remind them how much you value our rivers.Next, get networking. Take the time to contact any outdoor adventure communities or organizations (like Blueridge Outdoors!) and work together to make a team effort.Lastly, hype it up. Tell your friends, family, and anyone who appreciates the water around us about your love for the outdoors lifestyle. The goal is to get people talking.Virginia is close to giving its devoted paddlers and river travelers the “Freedom to Float”. Join in on taking these last crucial steps and become part of the solution.
A new report from the National Credit Union Administration (NCUA) finds that loan delinquencies and charge-off rates are rising at the nation’s CUs.Much of this is due to a happy development: credit union lending has risen by a healthy amount recently.In fact, loans outstanding were up 10.7% in the year ending in the first quarter of 2016. Total loans reached $799.5 billion at the end of the first quarter, NCUA said.New auto loan originations rose 15.4%, accounting for the biggest part of the overall increase. Used auto loans were up by 13.2%.CUs are lending more to member businesses. These loans grew by 13%. continue reading » 8SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
The year began with Mr. Trump embroiled in a monthslong impeachment proceeding, which scrutinized his pressure campaign on the president of Ukraine to investigate his political rivals at home. That was, in retrospect, the easy part of the year.From the Democratic primary race emerged perhaps the trickiest opponent for him — Joseph R. Biden Jr., a centrist with moderate appeal. A pandemic killed more than 230,000 people in the United States and devastated the economic gains that were to serve as his main argument for re-election.But Mr. Trump was already holding rage-filled campaign rallies in January, warning that Democrats’ efforts to remove him from office were designed to “nullify the ballots of tens of millions of patriotic Americans.” He returned to the campaign trail, often visiting states where Democrats were holding primary contests. In the closing days of the campaign, Mr. Trump barnstormed the country as if the virus that defined much of his year did not exist. His lagging position in the polls was evident in his grueling travel schedule, which had him seeking to shore up votes in states that he won in 2016, with up to five stops a day.Instead of focusing his closing argument on the economy, he accused doctors of fabricating coronavirus cases in order to make money, complained about the bitter cold in states like Michigan, and hinted he wanted to fire Dr. Anthony S. Fauci, the nation’s top infectious disease expert. His last stop before Election Day was Michigan, a repeat of his travel schedule four years ago. Mr. Trump hosted Judge Barrett, her family and Republican lawmakers at the White House for a formal announcement ceremony the next weekend. There was no social distancing and few wore masks. Mr. Trump downplayed the risks of the coronavirus as it began to take hold in February. In an Oval Office address in March, he struggled to acknowledge the deepening crisis while continuing to diminish its threat to the country’s future. He described it ominously as a “foreign virus,” blaming China and Europe. The Senate, divided almost entirely along party lines, acquitted Mr. Trump of charges that he abused his power and obstructed Congress to aid his own re-election. The president hailed it as a victory, calling the entire impeachment “corrupt.” After moving the location of the Republican National Convention twice, Mr. Trump eventually decided to deliver his renomination speech from the South Lawn of the White House in August. Updated Nov. 2, 2020, 11:37 p.m. ET His campaign maintained that holding the premier political event of the presidential race on government property was not a violation of the Hatch Act. But the event symbolized a final demolition of the boundary between governing and campaigning that the president had been eroding for years. After George Floyd, an unarmed Black man, was killed in the custody of the Minneapolis police, protests against racial injustice spread throughout the country. A chemical spray and rubber bullets were used to clear peaceful protesters from Lafayette Park, in front of the White House, so that Mr. Trump could stage a photo op at a nearby church that had been vandalized days before. Nov. 2, 2020This was not the 2020 that President Trump had envisioned for himself.- Advertisement – In April, Mr. Trump tweeted “LIBERATE MICHIGAN!” and “LIBERATE MINNESOTA!” — encouraging his supporters to protest coronavirus restrictions imposed by Democratic governors. His appeal to his base furthered partisan divisions on the pandemic response. – Advertisement – Standing in front of Mount Rushmore just before the Fourth of July, Mr. Trump used an official presidential address to wage a culture war against a straw-man version of the left that he portrayed as inciting mayhem and moving the country toward totalitarianism.He tried to position himself as the candidate of law and order, claiming that “angry mobs” wanted to tear down statues of the nation’s founders and “unleash a wave of violent crime in our cities.” The Trump campaign hyped a June rally in Tulsa, Okla., as the president’s triumphant return to the stump. Though the campaign claimed that nearly one million people had registered for tickets, Mr. Trump spoke in front of a mostly empty arena. It was a sign that even his own supporters were frightened of the coronavirus, despite his repeated attempts to dismiss it. Assured acquittal by the Republican-led Senate, Mr. Trump used his State of the Union address to make the case for a second term. The most memorable moment of the evening was delivered by Speaker Nancy Pelosi, who ostentatiously ripped up her copy of the president’s speech at its conclusion. And Republican lawmakers’ cheers of “Four more years!” made it clear that both parties were interested in creating a partisan spectacle. Eight days before the election, Mr. Trump won confirmation of his third Supreme Court justice. He immediately hosted a nighttime ceremony on the White House lawn to swear in Ms. Barrett. The outdoor gathering was a mirror image of the potential superspreader event he held a month earlier to announce her nomination. – Advertisement – Less than 48 hours after the debate, Mr. Trump announced on Twitter that he and the first lady, Melania Trump, had tested positive for the coronavirus. He was taken to Walter Reed National Military Medical Center, where he remained for three days. The White House physician, Dr. Sean P. Conley, delivered confusion and obfuscation with his updates on the president’s condition.Upon his return to the White House, Mr. Trump was unrepentant about his efforts to play down the virus. “Don’t let it dominate your lives,” he urged Americans. Mr. Trump roared back to the campaign trail after his recovery. In the final weeks of the race, as the number of coronavirus cases skyrocketed nationwide, his leading message to supporters was to trust him that the worst of the pandemic was over. He railed against the news media for continuing to cover the health crisis. The day after Justice Ruth Bader Ginsburg died in September, Mr. Trump and Senator Mitch McConnell, the majority leader, were already in contact with Judge Amy Coney Barrett about filling the opening on the Supreme Court. Two days later, they offered her the nomination. The first coronavirus outbreak in the spring hit hard in Northeastern cities and spots on the West Coast, but a second surge in the summer spread across a wider portion of the country. Hospitals fought to contain the surge. – Advertisement –
Categories: Letters to the Editor, Opinion I think president Trump’s recent proposal for a military parade in Washington, D.C., is a bad idea. He seems to want to turn the streets of our capital into replicas of the streets of Moscow or the streets of Pyongyang, North Korea.I concede grudgingly that the vast amount of money we spend on the military may be necessary for our defense, but I’m still somewhat appalled by the fact that we spend more on our military than all of our Western allies put together. However, although our military spending may unfortunately be necessary, I don’t think it’s something we should celebrate with a parade.Deep down however, my objection to a military parade is that it’s clearly a typical self-aggrandizing Trump maneuver. I wouldn’t be surprised if he would like our troops to salute him with a “Heil Trump” as they passed the reviewing stand.John VohrNorthvilleMore from The Daily Gazette:Gov. Andrew Cuomo’s press conference for Sunday, Oct. 18Cuomo calls for clarity on administering vaccineEDITORIAL: Beware of voter intimidationEDITORIAL: Thruway tax unfair to working motoristsEDITORIAL: Find a way to get family members into nursing homes
Among the forms of harassment identified in the survey were being the subject of sex jokes, receiving unwanted photos, videos and audio recordings, as well as being seduced by coworkers.Read also: Ignorance, misguided policies allow rape culture to thriveThey were made through various digital communication platforms, such as messaging apps, video conference apps and email.The survey also revealed that 94 percent of victims chose to remain silent and not report the incidents to their human resources department. A majority believed their report would not be taken seriously or addressed, while some were afraid that reporting such cases would only put their jobs at risk.“Our survey also found that 85 percent of companies don’t have antiharassment policy, allowing sexual abuse and harassment to persist,” Never Okay Project initiator Alvin Nicola said on Friday. The project’s goal is to combat sexual harassment at workplaces.Never Okay Project and SAFEnet urged companies to formulate strategies to crack down on sexual harassment in their work environment. They also encouraged workers to reject the “normalization of harassment” and instead push their workplaces to build antiharassment initiatives.Topics : Workers are still facing harassment from superiors and colleagues through communication platforms while working from home during the COVID-19 outbreak, according to an online survey.A joint survey by the Southeast Asia Freedom of Expression Network (SAFEnet) and Never Okay Project found 86 of 315 respondents claimed they were sexually harassed while working from home and 68 said they witnessed sexual advances being made on their colleagues. Thirty respondents claimed they both experienced and witnessed such unwanted advances.The survey was conducted from April 6 to 19 involving women, men and transgender workers who are permanent employees, contract workers and freelancers across the country.